In VMware PowerCLI, you can use the Set-ScsiLunPath cmdlet to modify the configuration of paths for a specific SCSI LUN. To modify paths for multiple LUNs, you can use a loop to iterate through the LUNs and apply the necessary changes. Here’s an example script that demonstrates how to set paths for multiple LUNs using PowerCLI:

# Connect to your vCenter Server
Connect-VIServer -Server YourVCenterServer -User YourUsername -Password YourPassword

# Get the ESXi hosts where the LUNs are presented
$ESXiHosts = Get-VMHost -Name "ESXiHostName1", "ESXiHostName2"  # Add ESXi host names

# Define the list of SCSI LUN IDs and paths to configure
$LUNPaths = @{
    "naa.6006016055502500d900000000000000" = "vmhba1:C0:T0:L0",
    "naa.6006016055502500d900000000000001" = "vmhba1:C0:T0:L1"
    # Add more LUN IDs and paths as needed
}

# Loop through ESXi hosts
foreach ($ESXiHost in $ESXiHosts) {
    # Get the list of LUNs for the host
    $LUNs = Get-ScsiLun -VMHost $ESXiHost

    # Loop through LUNs and set paths
    foreach ($LUN in $LUNs) {
        $LUNId = $LUN.CanonicalName

        if ($LUNPaths.ContainsKey($LUNId)) {
            $Path = $LUNPaths[$LUNId]
            Set-ScsiLunPath -ScsiLun $LUN -Path $Path -Confirm:$false
            Write-Host "Path set for LUN $($LUN.CanonicalName) on $($ESXiHost.Name)"
        } else {
            Write-Host "Path not configured for LUN $($LUN.CanonicalName) on $($ESXiHost.Name)"
        }
    }
}

# Disconnect from the vCenter Server
Disconnect-VIServer -Server * -Confirm:$false

Replace YourVCenterServer, YourUsername, YourPassword, ESXiHostName1, ESXiHostName2, and the example LUN IDs and paths with your actual vCenter Server details, ESXi host names, and the desired LUN configurations.

In this script:

1. Connect to the vCenter Server using Connect-VIServer.
2. Get the list of ESXi hosts using Get-VMHost.
3. Define the LUN IDs and paths in the $LUNPaths hash table.
4. Loop through ESXi hosts and retrieve the list of LUNs using Get-ScsiLun.
5. Loop through LUNs, check if a path is defined in the $LUNPaths hash table, and use Set-ScsiLunPath to set the path.
6. Disconnect from the vCenter Server using Disconnect-VIServer.